Xeljanz XR

Xeljanz XR (tofacitinib extended-release) is a prescription medication that belongs to a class of drugs known as Janus kinase inhibitors (JAK inhibitors). It is used to treat adults with moderate to severe rheumatoid arthritis (RA) who have not responded well to other treatments.


The usual starting dose of Xeljanz XR is 11 mg taken once daily with or without food. The dose may be adjusted based on the patient's response and side effects. Patients should not exceed a dose of 22 mg per day.

How it works:

Xeljanz XR works by inhibiting the Janus kinase (JAK) pathway, which is involved in the immune response that causes inflammation in the joints of people with RA. By inhibiting this pathway, Xeljanz XR reduces inflammation and improves symptoms such as pain and stiffness.

Side effects:

The most common side effects of Xeljanz XR include upper respiratory tract infections, headache, and diarrhea. Patients may also experience an increased risk of serious infections, including tuberculosis (TB) and fungal infections. Other serious side effects may include liver problems, cancer, and blood clots.

Patients should tell their healthcare provider immediately if they experience any symptoms of infection, such as fever, cough, or persistent flu-like symptoms. Patients should also report any symptoms of liver problems, such as yellowing of the skin or eyes, dark urine, or abdominal pain.


Before taking Xeljanz XR, patients should tell their healthcare provider about all their medical conditions and any medications they are taking, including over-the-counter drugs and herbal supplements. Patients should also tell their healthcare provider if they have a history of infections or have been exposed to TB.

Patients should not receive live vaccines while taking Xeljanz XR. Patients should also avoid drinking alcohol while taking this medication.


Xeljanz XR is a medication that can be effective in treating moderate to severe RA, but it may also cause serious side effects. Patients should be aware of the risks and benefits of this medication and work closely with their healthcare provider to manage their symptoms and monitor for any potential side effects. If you have any questions or concerns about Xeljanz XR, please speak to your healthcare provider.


The information provided here is for educational purposes only and does not replace the advice of a healthcare professional. It is important to consult with your healthcare provider before starting any new medication or making changes to your current treatment plan. The information provided is based on the most current information available and is subject to change as new information becomes available. The manufacturer of medication is responsible for the accuracy and completeness of the product information provided.