Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a type of arthritis that primarily affects the spine, but can also affect other joints and organs. It is a chronic condition that develops slowly over time, typically beginning in the late teens or early twenties. Here's a detailed overview of the condition to be published on a website:


The symptoms of AS can vary from person to person, but the most common symptom is chronic pain and stiffness in the lower back, which can be worse in the morning or after periods of inactivity. Other symptoms may include:

• Pain and stiffness in other areas of the spine, such as the neck

• Pain and stiffness in the hips, shoulders, and other joints

• Fatigue • Loss of appetite

• Weight loss

• Eye inflammation

• Difficulty breathing


The exact cause of AS is unknown, but it is believed to be related to a combination of genetic and environmental factors. The HLA-B27 gene is strongly associated with the condition, and it is believed that the gene interacts with certain environmental triggers, such as infections, to cause the condition to develop.


Diagnosis of AS typically involves a combination of a physical exam, medical history, and imaging tests. The doctor will look for signs of inflammation in the joints and may order X-rays, MRI, or CT scans to look for evidence of damage to the joints and spine.


There is currently no cure for AS, but treatment can help manage symptoms and prevent or slow the progression of the condition. Treatment options may include:

• Nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce pain and inflammation

• Disease-modifying antirheumatic drugs (DMARDs) to slow the progression of the condition

• Biologic drugs to target specific proteins in the immune system that are involved in the development of AS

• Physical therapy to improve mobility and strength

• Lifestyle changes, such as exercise, quitting smoking, and maintaining a healthy weight


If left untreated, AS can lead to severe spinal deformities and difficulty breathing. It can also cause inflammation in other organs, such as the eyes and heart, leading to serious complications. However, with proper treatment and management, many people with AS are able to lead normal, active lives.


Ankylosing spondylitis is a chronic condition that can cause pain and stiffness in the spine and other joints. While there is no cure for the condition, treatment can help manage symptoms and prevent or slow the progression of the condition. If you are experiencing chronic pain or stiffness in your back or other joints, talk to your doctor about getting a diagnosis and starting treatment.